Compressing multiple PET scan visits into one
Positron Emission Tomography (PET) is a medical imaging technique invaluable for locating tumors by providing images of glucose metabolism. PET images with other molecular tracers can provide important complementary information and a more comprehensive view of the disease. Nevertheless, they are currently underutilized because they require a second visit, weeks later, for a second scan. This option is not only expensive but also inacurate, as significant misalignments between scans may occur. This project has developed new technology enabling two tracers to be imaged in one PET scan, decreasing cost and improving the information content. Applications for a more personalized radiotherapy planning and assessment are being explored.
Name & Contact
Team mPET
Project status
M+Visión project Jan 2012 – Jun 2014
On exit from M+Visión : seeking research support;
Fellows supported by Advanced Fellowship (co-fund program)
Sector
Nuclear medicine. Medical imaging. PET.
Fellows
Joaquín L. Herraíz, Eduardo Lage, Vicente Parot, Shivang Dave
Collaborators
Jose Manuel Udias, Jacobo Cal-Gonzalez, Elena Herranz
UCM
Juan José Vaquero
UC3M
Steve Moore, Mi-Ae Park, Arkadiusz Sitek | Radiology
BWH
Jose Venegas
Dept. of Anesthesia, MGH
Francisca Mulero, Jorge Luis Martinez
CNIO
Students
Jacobo Cal-Gonzalez, Elena Herranz
UCM
Santiago Peña
UC3M
Simulation of Triple Coincidences in PET. J. Cal-González, E. Lage, E. Herranz, E. Vicente, J. M. Udias, S. R. Dave, V. Parot, and J. L. Herraiz – Phys Med Biol. 2015 Jan 7;60(1):117-36. doi: 10.1088/0031-9155/60/1/117.
mPET: Herramienta innovadora para imagen PET multitrazador. J. L. Herraiz, F. Mulero, V. Parot, S. Dave, S. Moore, J.M. Udias, J.J. Vaquero & E. Lage. Rev Esp Med Nucl Imagen Mol. 2014;33(Supl 1):119
Multiplexed PET in Clinical Scanners based on Triple Coincidences. J. L. Herraiz, S. C. Moore, M. Ciervo, S. Espana, J. Ruiz-Cabello, E. Lage – IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA 2014. Oral presentation
A prompt-gamma correction method for non-standard PET radionuclides based on the detection of triple coincidences. J. L. Herraiz, S. C. Moore, V. Parot, S.R. Dave, M. Park, S. Yoo, W. Lee, H. Kim, E. Lage – IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA 2014. Oral presentation
Spatiotemporal Total Variation Reconstruction for Dynamic PET. J. F. P. J. Abascal, E. Lage, M. E. Martino, J.L. Herraiz, M. Desco, J. J. Vaquero – IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA 2014. Oral presentation
Fully Bayesian Image Estimation Software for GATE Simulations. J. L. Herraiz, S. Yip, R. Berbeco, A. Sitek – GATE Users Workshop at IEEE Nuclear Science Symposium and Medical Imaging Conference, Seattle, USA 2014. Oral presentation
A New Approach for Multiplexed PET Imaging. V. Parot, J. L. Herraiz, S.R. Dave, J. M. Udias, S. C. Moore, M. Park, J. J. Vaquero and E. Lage – IEEE Nuclear Science Symposium and Medical Imaging Conference, Seoul, South Korea 2013. Oral presentation
Recovery of multi-interaction photon events to improve the performance of PET scanners. E. Lage, V. Parot, J. M. Udias, S. C. Moore, M. Park, J. J. Vaquero, A. Sitek, S. R. Dave and J. L. Herraiz. IEEE Nuclear Science Symposium and Medical Imaging Conference, Seoul, South Korea 2013. Poster Presentation
Simulation of Triple Coincidences in PET. J. Cal-Gonzalez, E. Herranz, J.M. Udias, S. R. Dave, V. Parot, E. Lage and J. L. Herraiz – IEEE Nuclear Science Symposium and Medical Imaging Conference, Seoul, South Korea 2013. Poster presentation
Production of positron-gamma emitters for multiplexed PET (mPET) imaging. by J. L. Herraiz, E. Lage, V. Parot, S. R. Dave, J. M. Udias, J. J. Vaquero, A. Muñoz and L. M. Fraile – IEEE Nuclear Science Symposium and Medical Imaging Conference, Seoul, South Korea 2013. Poster presentation.
Triple coincidences in PET: New applications and technology improvements. JPNM seminar in Nuclear Medicine and Molecular imaging, Harvard Medical School, Cambridge, MA, 2013. 2.(Invited)
Simultaneous dual-radionuclide PET using triple coincidence information. Medical Physics Grad Rounds, Memorial Sloan-Kettering Cancer Center, New York, USA, 2012. (Invited)
Disclosures
Method to Perform Multiple Radiotracer Positron Emission Tomography Imaging (MIT 15438)
Inter-Detector Scatter Enhanced Positron Emission Tomography (MIT 15769)
Method to Improve the Image Quality of Positron Emission Tomography When Using Non-Standard Isotopes Based on Triple Coincidences (MIT 16135)
Normalization Correction for Inter-Detector Scatter Enhanced Positron Emission Tomography (MIT 16136)
Patents
Multiplexable Emisson Tomography. (MIT 15438)
Patent Cooperation Treaty Serial No. PCT/US2013/038846, Filed April 30, 2013
United States of America Serial No. 14/396805, Filed October 24, 2014
System And Method For Inter-Detector Scatter Enhanced Emission Tomography (MIT 15769)
Patent Cooperation Treaty Serial No. PCT/US2013/068858, Filed November 7, 2013
System And Method To Improve Image Quality Of Emission Tomography When Using Advanced Radionuclides (MIT 16135)
Patent Cooperation Treaty Serial No. PCT/US2014/045220, Filed July 2, 2014
Normalization Correction For Multiple-Detection Enhanced Emission Tomography
(MIT 16136)
Patent Cooperation Treaty Serial No. PCT/US2014/043826, Filed June 24, 2014
http://iopscience.iop.org/0031-9155/60/1/117/article
Entrevista en el mundo
http://www.elmundo.es/madrid/2014/05/03/53653b7bca4741d96b8b456f.html
Jacobo Cal-Gonzalez received 3rd place in best student presentation, IEEE Nuclear Science Symposium and Medical Imaging Conference, Seoul, South Korea 2013. Read more+
IE Business School Venture Day 2012 – semifinalist
Media and updates
March 2014:
Team member Eduardo Lage was interviewed by El Mundo. Read more+
November 2013:
Student Jacobo Cal-Gonzalez, a PhD from UCM in Madrid, won 3rd place for Best Student in the IEEE meeting in Seoul, Korea, under a paper related to mPET
Team member & M+Visión Senior Fellow Joaquín López Herraiz made five presentations at the 2013 IEEE Nuclear Sciences Symposium and Medical Imaging Conference in Seoul.
For more information, please visit the Venture Days page +